{"id":4899,"date":"2026-11-05T09:24:24","date_gmt":"2026-11-05T09:24:24","guid":{"rendered":"https:\/\/www.laboratoriosrubio.com\/?p=4899"},"modified":"2026-11-05T09:25:38","modified_gmt":"2026-11-05T09:25:38","slug":"the-lancet-publishes-the-litmus-study-which-evaluated-rubio-metabolomics-owliver","status":"publish","type":"post","link":"https:\/\/www.laboratoriosrubio.com\/en\/the-lancet-publishes-the-litmus-study-which-evaluated-rubio-metabolomics-owliver\/","title":{"rendered":"The Lancet publishes the LITMUS study, which evaluated Rubi\u00f3 Metabolomics\u2019 OWLiver"},"content":{"rendered":"<p>Rubi\u00f3 Metabolomics contributes with its OWLiver to the international LITMUS study published in The Lancet, one of the largest prospective evaluations to date of non-invasive biomarkers for metabolic dysfunction-associated steatotic liver disease (MASLD) and its inflammatory form, metabolic dysfunction-associated steatohepatitis (MASH), providing new evidence on OWLiver for the identification of patients with at-risk MASH. <\/p>\n<p>The study included 1,590 participants from 13 countries and evaluated a broad range of biomarkers against centrally assessed liver histology. Among the technologies evaluated was OWLiver, a metabolomics-based blood test developed by Rubi\u00f3 Metabolomics for the non-invasive assessment of MASH and at-risk MASH. The OWLiver analyses included in the study were performed at Rubi\u00f3 Metabolomics\u2019 facilities in Derio, Bizkaia. <\/p>\n<p>In particular, OWLiver-MASEF was evaluated for the identification of at-risk MASH, a population of particular relevance due to the presence of MASH together with significant liver fibrosis. The publication therefore provides new evidence on OWLiver in a large prospective international cohort and contributes to further defining the role of non-invasive biomarkers in identifying patients with higher-risk forms of the disease. <\/p>\n<p>The study also assessed the potential of biomarkers to support clinical trial recruitment. In this setting, OWLiver-MASH showed potential as a prescreening tool for patients with at-risk MASH before confirmatory biopsy. <\/p>\n<p>READ THE PUBLICATION <\/p>\n<p>Vali Y, Wonders K, Lee J, et al. Non-invasive tests in metabolic dysfunction-associated steatotic liver disease: the LITMUS prospective multicentre diagnostic accuracy study. The Lancet. 2026;408:1850\u20131865. DOI: 10.1016\/S0140-6736(26)01145-1 <\/p>\n<p>Funding and disclosures <\/p>\n<p>The LITMUS consortium was funded through the Innovative Medicines Initiative 2 Joint Undertaking and by the contributing industry partners. This Joint Undertaking receives support from the European Union\u2019s Horizon 2020 research and innovation programme and EFPIA. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Rubi\u00f3 Metabolomics contributes with its OWLiver to the international LITMUS study published in The Lancet, one of the largest prospective evaluations to date of non-invasive biomarkers for metabolic dysfunction-associated steatotic liver disease (MASLD) and its inflammatory form, metabolic dysfunction-associated steatohepatitis (MASH), providing new evidence on OWLiver for the identification of patients with at-risk MASH. The [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[14],"tags":[],"class_list":["post-4899","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>The Lancet publishes the LITMUS study, which evaluated Rubi\u00f3 Metabolomics\u2019 OWLiver - Laboratorios Rubi\u00f3<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.laboratoriosrubio.com\/en\/the-lancet-publishes-the-litmus-study-which-evaluated-rubio-metabolomics-owliver\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The Lancet publishes the LITMUS study, which evaluated Rubi\u00f3 Metabolomics\u2019 OWLiver - Laboratorios Rubi\u00f3\" \/>\n<meta property=\"og:description\" content=\"Rubi\u00f3 Metabolomics contributes with its OWLiver to the international LITMUS study published in The Lancet, one of the largest prospective evaluations to date of non-invasive biomarkers for metabolic dysfunction-associated steatotic liver disease (MASLD) and its inflammatory form, metabolic dysfunction-associated steatohepatitis (MASH), providing new evidence on OWLiver for the identification of patients with at-risk MASH. 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